Endocrine Abstracts

Background: Old age is proven to be one of the greatest danger factors for intensively dealing with COVID-19 patients. Stoutness and diabetes are enhancers of dangers among COVID-19 patients. In any case, there exists restricted proof for the modifiable danger components, for example, bodyweight which is an indicator of the Intensive Care Unit and its need among type 2 diabetes patients. In this review, the subject of body weight as an indicator of ICU confirmations will be in...

Background: The consequences of overt hypothyroidism on the central nervous system are well known. Interestingly, there is less proof in regards to the impacts of subclinical hypothyroidism (SCH) on the cognitive functions among elderly subjects. Studies from various countries including India have shown a variable association between SCH and cognitive dysfunction. This study planned to survey the event of cognitive impairment among the older Indian subjects who were introducin...

Introduction: Increase in global childhood obesity is considered to be one of the detrimental problems all across the world. It is well known that about every 1 in every 300-500 infants suffers from Type-1 Diabetes Mellitus. Obesity has been directly associated with elevation of blood sugar and HbA1c.Objective: This study investigates the prevalence of obesity in Type-1 DM and the distribution of sex, age and its correlation with HbA1.<p class="abste...

Introduction: Acute and chronic alcohol intake and alcohol withdrawal induce dysfunction of neuroendocrine and other regulatory systems. The expression ‘neuroendocrine dysfunction’ alludes to an assortment of conditions brought about by imbalances in the body’s chemical creation straightforwardly connected with the pituitary, nerve center, and their tomahawks following TBI.Aims: This study aimed to assess a possible hypothalamo-pituitary-a...

Introduction: Hyponatraemia is a common electrolyte abnormality seen among hospitalised patients. We describe below, an inpatient seen with severe hyponatraemia.Case description: 71yr old gentleman with no co-morbidities, admitted with acute confusion and slurred speech. Physical examination: Observations: Temperature 35C, heart rate 53/min, otherwise stable. GCS 15/15, no focal neurolo...

A 50-year-old female with complex chronic hypoxic congenital heart disease was incidentally identified with a 2 cm extra-vesicular nodule of the bladder during a surveillance ultrasound scan. Suspicious of a bladder carcinoma she uneventfully underwent open partial cystectomy. Histology confirmed a bladder paraganglioma with local lymph node invasion. Post-operative biochemical work-up disclosed raised plasma metanephrine”s: normetadrenaline 7073 pmol/l (120-1180 pmol/l),...

Background: For a thorough evaluation of the pituitary gland, it is important to understand its typical structure, including the physiological differences in size and form across age groups in both males and females.Objectives: To use magnetic resonance images to examine the size, shape, and average normal volume of the normal pituitary gland at various age groups in both genders (MRI).Material and methods: 200 individuals who unde...

A 71 year old gentleman, known to have Renal Cell Carcinoma with metastasis to lung, mediastinum, spine and liver, was transferred to our services for management of T2/T3 Spinal root impingement. On admission he was noted to have severe hypercalcemia of 3.33mmol/l, mild hypophosphatemia 0.8mmol/land an ongoing acute kidney injury. He had appropriate initial management with intravenous fluids, and was started on dexamethasone 8 mg with PPI cover for the spinal metastasis. His i...

Introduction: Checkpoint inhibitor (CPI) related endocrine toxicities are increasingly commonly with the use of these new cancer agents. With one of the largest cancer departments in UK, we studied the clinical management and outcome of patients who developed different endocrine toxicities over the last five years, with the use of CTLA-4, PD-1 and PDL-1 agents.Methods: All patients treated with CPI between 1 Jan 2014 to 31 Jan 2019 were included for the ...

Aim: Anti-thyroid treatment with carbimazole or propylthiouracil is the first-line treatment for autoimmune thyrotoxicosis in the UK. Following 12–18 months treatment there is a significant relapse rate (at least 50%). This study analysed the demographics and clinical features of 100 patients with relapsed thyrotoxicosis to examine which variables are predictive of relapse.Methods: This retrospective study included adult patients identified using ou...